In the premiere episode of "Coach Prime," the college football world is set ablaze as Pro Football Hall of Famer Deion Sanders takes the helm as the head coach at the University of Colorado, Boulder. Ignoring the swirl of criticism surrounding his move, Coach Prime remains steadfast, understanding that he has one singular mission-to turn around a struggling program and redefine its destiny.

Off-season practice and conditioning are over, and the Fall season is approaching. The Colorado Buffaloes face an uphill battle against TCU, the formidable 2022 National Championship runner-up. Projections are grim, and critics dismiss the Buffaloes' chances against this powerhouse. However, Coach Prime's relentless spirit ignites a spark in the team.

The Colorado Buffaloes shocked the sports world with their win over TCU. The upset moved the Buffaloes into college football's top 25 rankings. With National sports shows ascending to Boulder to witness the "Prime Effect," the Colorado Buffaloes prepare for back-to-back rival games against Nebraska and Colorado State.

Coach Prime leads the Colorado Buffaloes on an undefeated streak, gearing up for two epic Pac-12 showdowns against Oregon and USC. Buffalos look to stay undefeated with Heisman hopeful Travis Hunter sidelined by injury.

If adversity reveals character, the Buffalos are challenged like never before. Travis Hunter and Shilo Sanders return to the field. Coach Prime challenges his team to rediscover the passion that fueled their earlier success.

In the season finale, the Buffaloes finally answer questions surrounding the team's ability to unite. With the team still in contention for a bowl game, the Buffaloes must put aside their struggles for the team's sake.

A new season brings a new conference and new beginnings for the Buffaloes, highlighted by talent upgrades on National Signing Day and Warren Sapp joining the coaching staff. After a busy offseason that includes Paris Fashion Week and a video game cover shoot, the season arrives with tough matchups against North Dakota State and Nebraska.

Coach Prime and the Buffaloes must respond to the season’s increasing pressure. Deion supports Shilo in the wake of the injury he suffered against Nebraska, while Travis Hunter eyes a rematch against Colorado State after enduring his own injury against the Rams last year. And the offensive must rise to the occasion in a dramatic Big 12 showdown with Baylor.

The team’s brotherly bonds deepen as the Buffaloes hit the road to face UCF. After a conversation with Coach Prime and Charles Woodson, Travis Hunter puts on a show on both sides of the ball. Jimmy Horn Jr. enjoys an emotional Florida homecoming, and the team lets off steam while shifting its focus to the heart of the season ahead.

The Buffaloes seek to bounce back and reach bowl eligibility after Travis Hunter suffers an injury in a loss to Kansas State. The team faces Big 12 foes Arizona and Cincinnati while defensive end Nikhil Webb-Walker inspires the locker room with his battle against lymphoma.

After the Buffaloes endure a chaotic game at Texas Tech, Deion and Travis Hunter seek solace on the lake, sharing a love of fishing as they reflect on their bond. CU superfan “Miss Peggy” commemorates her 100 th birthday, Travis and his fiancée dive into their wedding plans, and the team celebrates Thanksgiving as it builds to the climax of the regular season.